Issue 8, 2011
From the journal:

Catalysis Science & Technology

Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketonehydrogenation using tridentate phosphine-diamine ligands†

Scott D. Phillips,a   Kristian H. O. Andersson,b   Nina Kann,*b   Michael T. Kuntz,c   Marcia B. France,*c   Piotr Wawrzyniaka  and  Matthew L. Clarke*a  

* Corresponding authors

a School of Chemistry, University of St Andrews, St Andrews, Fife, UK
E-mail: mc28@st-andrews.ac.uk
Fax: +44 (0) 1334 463808
Tel: +44 (0) 1334 463850

b Department of Chemical and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden

c Department of Chemistry, Washington and Lee University, Lexington, USA

Abstract

Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.

Graphical abstract: Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1CY00253H
Article type
Communication
Submitted
05 Jul 2011
Accepted
15 Aug 2011
First published
05 Sep 2011

Catal. Sci. Technol., 2011,1, 1336-1339

Permissions

Request permissions

Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

S. D. Phillips, K. H. O. Andersson, N. Kann, M. T. Kuntz, M. B. France, P. Wawrzyniak and M. L. Clarke, Catal. Sci. Technol., 2011, 1, 1336 DOI: 10.1039/C1CY00253H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements