Issue 3, 2012

Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

Abstract

A new type of primary–tertiary diamine salt prepared can be used as a catalyst for direct aldol reaction and can display high yields, diastereoselectivities (up to 99 : 1), and enantiomeric excesses (up to 98%), by using stoichiometric amounts of cyclic ketones and various aryl aldehydes in the presence of water. This new catalyst can also be efficiently applied in large-scale reactions with the enantioselectivity being maintained at the same level, which indicates the potential for applications in industry.

Graphical abstract: Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

Supplementary files

Article information

Article type
Paper
Submitted
11 Aug 2011
Accepted
08 Nov 2011
First published
05 Dec 2011

Catal. Sci. Technol., 2012,2, 547-553

Highly efficient direct large-scale stoichiometric aldol reactions catalyzed by a new diamine salt in the presence of water

J. Huang, G. Chen, X. Fu, C. Li, C. Wu and Q. Miao, Catal. Sci. Technol., 2012, 2, 547 DOI: 10.1039/C1CY00318F

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