Issue 1, 2012

Effective synthesis of 2,5-disubstituted tetrahydrofurans from glycerol by catalytic alkylation of ketones

Abstract

The [IrCl(cod)]2 catalyzed α-alkylation of substituted acetophenones with solketal followed by reduction and iron mediated cyclization provides 2,5-disubstituted tetrahydrofurans.

Graphical abstract: Effective synthesis of 2,5-disubstituted tetrahydrofurans from glycerol by catalytic alkylation of ketones

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2011
Accepted
22 Sep 2011
First published
18 Oct 2011

Green Chem., 2012,14, 55-57

Effective synthesis of 2,5-disubstituted tetrahydrofurans from glycerol by catalytic alkylation of ketones

M. Rueping and V. B. Phapale, Green Chem., 2012, 14, 55 DOI: 10.1039/C1GC15764G

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