Issue 11, 2011
From the journal:

Green Chemistry

Utilising hardly-water soluble substrates as a second phase enables the straightforward synthesis of chiral alcohols†

Christina Kohlmann,a   Nora Robertz,a   Susanne Leuchs,b   Lasse Greiner*ab  and  Shukralla Na’amniehc  

* Corresponding authors

a Institut für Technische und Makromolekulare Chemie, RWTH Aachen University, Worringer Weg 1, Aachen, Germany

b DECHEMA e. V., Karl-Winnacker-Institut, Theodor-Heuss-Allee 25, Frankfurt am Main, Germany
E-mail: greiner@dechema.de

c X-Zyme GmbH, Merrowingerplatz 1a, Düsseldorf, Germany

Abstract

So far, the alcohol dehydrogenase-catalysed conversion of longer chain aliphatic substrates has been challenging due to their low solubility in aqueous solution. However, by utilising the ketone directly as a second organic phase, the straightforward synthesis of long chain aliphatic chiral alcohols is enabled.

Graphical abstract: Utilising hardly-water soluble substrates as a second phase enables the straightforward synthesis of chiral alcohols

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Article information

DOI
https://doi.org/10.1039/C1GC15823F
Article type
Communication
Submitted
10 Jul 2011
Accepted
19 Aug 2011
First published
28 Sep 2011

Green Chem., 2011,13, 3093-3095

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Utilising hardly-water soluble substrates as a second phase enables the straightforward synthesis of chiral alcohols

C. Kohlmann, N. Robertz, S. Leuchs, L. Greiner and S. Na’amnieh, Green Chem., 2011, 13, 3093 DOI: 10.1039/C1GC15823F

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