Issue 8, 2011
From the journal:

MedChemComm

Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase†

Feihua Cao,a   Allan B. Gamble,a   Hye-Kyung Kim,a   Hideki Onagi,a   Mary J. Gresser,a   Jamie Kerr‡a  and  Christopher J. Easton*a  

* Corresponding authors

a ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, Research School of Chemistry, Australian National University, Canberra, Australia
E-mail: easton@rsc.anu.edu.au

Abstract

Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin.

Graphical abstract: Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

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Article information

DOI
https://doi.org/10.1039/C1MD00079A
Article type
Concise Article
Submitted
21 Mar 2011
Accepted
03 Jun 2011
First published
21 Jun 2011

Med. Chem. Commun., 2011,2, 760-763

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Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

F. Cao, A. B. Gamble, H. Kim, H. Onagi, M. J. Gresser, J. Kerr and C. J. Easton, Med. Chem. Commun., 2011, 2, 760 DOI: 10.1039/C1MD00079A

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