Issue 1, 2012
From the journal:

MedChemComm

Inhibitors of Stat5 protein signalling

Abbarna A. Cumaraswamy,a   Aleksandra Todic,a   Diana Resetca,a   Mark D. Mindenb  and  Patrick T. Gunning*a  

* Corresponding authors

a Department of Chemistry, University of Toronto, 3359 Mississauga Road North, Mississauga, ON, Canada
E-mail: patrick.gunning@utoronto.ca
Tel: +905-828-5354

b Princess Margaret Hospital, Ontario Cancer Institute, 610 University Avenue, Toronto, ON, Canada
E-mail: mark.minden@uhn.on.ca
Fax: +416-946-6546
Tel: +416.946.4501

Abstract

Evidence shows that signal transducer and activator of transcription 5 (Stat5) protein, a member of the STAT family of signalling proteins, plays a pivotal role in the progression of many human cancers including acute myeloid leukemias and prostate cancer. This mini-review outlines progress made towards identifying agents capable of silencing aberrant Stat5 signalling.

Graphical abstract: Inhibitors of Stat5 protein signalling

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Article information

DOI
https://doi.org/10.1039/C1MD00175B
Article type
Review Article
Submitted
07 Jul 2011
Accepted
25 Aug 2011
First published
03 Oct 2011

Med. Chem. Commun., 2012,3, 22-27

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Inhibitors of Stat5 protein signalling

A. A. Cumaraswamy, A. Todic, D. Resetca, M. D. Minden and P. T. Gunning, Med. Chem. Commun., 2012, 3, 22 DOI: 10.1039/C1MD00175B

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