Issue 12, 2011

Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

Abstract

A series of 15 heterocyclic butyrophenone analogues was synthesized as potential multi-target ligands. The compounds were assayed for their in vitro human D2 and 5-HT2A receptor affinity, and those compounds exhibiting the highest affinities were evaluated for binding affinity on D1, D3, 5-HT1A, 5-HT2C and 5-HT6 receptors.

Graphical abstract: Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

Supplementary files

Article information

Article type
Concise Article
Submitted
06 Aug 2011
Accepted
12 Sep 2011
First published
11 Oct 2011

Med. Chem. Commun., 2011,2, 1194-1200

Potential atypical antipsychotics: synthesis, binding affinity and SAR of new heterocyclic bioisosteric butyrophenone analogues as multitarget ligands

M. Barceló, E. Raviña, M. J. Varela, J. Brea, M. I. Loza and C. F. Masaguer, Med. Chem. Commun., 2011, 2, 1194 DOI: 10.1039/C1MD00202C

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