Synthesis and in vitroinsulin-mimetic activities of zinc(II) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

Hikaru Kawarada; Yutaka Yoshikawa; Hiroyuki Yasui; Shunsuke Kuwahara; Yoichi Habata; Ryota Saito

doi:10.1039/C1MT00009H

Synthesis and in vitroinsulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates†‡

Hikaru Kawarada,^a Yutaka Yoshikawa,^b Hiroyuki Yasui,^b Shunsuke Kuwahara,^a Yoichi Habata^a and Ryota Saito*^a

* Corresponding authors

^a Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan
E-mail: saito@chem.sci.toho-u.ac.jp
Fax: 81-47-472-1926
Tel: 81-47-472-1926

^b Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan

Abstract

Several Zn(II) complexes (2a–e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a–e), known drug candidates for diabetic complications, were synthesized and proved to have in vitroinsulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.

This article is part of the themed collection: Metallomics in Japan

Metallomics

Synthesis and in vitroinsulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates†‡

Abstract

Supplementary files

Article information

Download Citation

Search articles by author

Spotlight

Advertisements