Issue 6, 2011

Iron homeostasis and management of oxidative stress response in bacteria

Abstract

Iron is both an essential nutrient for the growth of microorganisms, as well as a dangerous metal due to its capacity to generate reactive oxygen species (ROS) via the Fenton reaction. For these reasons, bacteria must tightly control the uptake and storage of iron in a manner that restricts the build-up of ROS. Therefore, it is not surprising to find that the control of iron homeostasis and responses to oxidative stress are coordinated. The mechanisms concerned with these processes, and the interactions involved, are the subject of this review.

Graphical abstract: Iron homeostasis and management of oxidative stress response in bacteria

Article information

Article type
Minireview
Submitted
21 Feb 2011
Accepted
14 Apr 2011
First published
13 May 2011

Metallomics, 2011,3, 540-549

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