Issue 4, 2012

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

Abstract

A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.

Graphical abstract: A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

Supplementary files

Article information

Article type
Paper
Submitted
12 Aug 2011
Accepted
04 Oct 2011
First published
14 Oct 2011

Org. Biomol. Chem., 2012,10, 825-834

A formal [3+3]-annulation-based approach to pancratistatins: total synthesis of (±)-7-deoxy-pancratistatin and its 2-epi and 2,4-diepi analogues

O. Nieto-García, H. Lago-Santomé, F. Cagide-Fagín, J. C. Ortiz-Lara and R. Alonso, Org. Biomol. Chem., 2012, 10, 825 DOI: 10.1039/C1OB06374J

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