Issue 4, 2012

Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions

Abstract

A new and general strategy for highly functional furo[3,4-c]coumarins and related furyl coumarin derivatives has been developed, which is based on an extraordinarily facile intramolecular Wittig reaction, starting from α,β-unsaturated ketones, tributylphosphine, and acyl chlorides. The phosphorus ylides were proposed to be the key intermediates for constructing the crucial furan ring, leading to a wide variety of substituted furyl coumarins in one step.

Graphical abstract: Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions

Supplementary files

Article information

Article type
Paper
Submitted
14 Sep 2011
Accepted
14 Oct 2011
First published
17 Oct 2011

Org. Biomol. Chem., 2012,10, 843-847

Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions

Y. Jang, S. Syu, Y. Chen, M. Yang and W. Lin, Org. Biomol. Chem., 2012, 10, 843 DOI: 10.1039/C1OB06571H

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