Issue 8, 2012
From the journal:

Analyst

Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry†

Jia Liu,a   Chengsen Zhang,a   Jiamu Suna  and  Hai Luo*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
E-mail: hluo@pku.edu.cn
Fax: +86-10-62751708
Tel: +86-10-62751499

Abstract

We describe complexation reactions of insulin and other proteins with metal ions generated from the substrate surface by laser irradiation in laser desorption spray post-ionization mass spectrometry (LDSPI-MS). This particular type of complexation reaction in LDSPI-MS was investigated for the first time, which indicated that the mechanistic process of LDSPI-MS might be much more complicated than that proposed before for similar methods.

Graphical abstract: Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry

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Article information

DOI
https://doi.org/10.1039/C2AN16090K
Article type
Communication
Submitted
11 Nov 2011
Accepted
10 Jan 2012
First published
20 Jan 2012

Analyst, 2012,137, 1764-1767

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Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry

J. Liu, C. Zhang, J. Sun and H. Luo, Analyst, 2012, 137, 1764 DOI: 10.1039/C2AN16090K

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