Issue 21, 2012
From the journal:

Analyst

Tracing nanoparticlesin vivo: a new general synthesis of positron emitting metal oxidenanoparticles by proton beam activation†

Carlos Pérez-Campaña,a   Vanessa Gómez-Vallejo,a   Abraham Martin,a   Eneko San Sebastián,a   Sergio E. Moya,b   Torsten Reese,a   Ronald F. Ziolo*c  and  Jordi Llop*a  

* Corresponding authors

a Molecular Imaging Unit, CIC biomaGUNE, Paseo Miramon 182, San Sebastian, Spain
E-mail: jllop@cicbiomagune.es
Tel: +34 943005333

b Biosurfaces Unit, CIC biomaGUNE, Paseo Miramon 182, San Sebastian, Spain

c Advanced Materials Department, Centro de Investigación en Química Aplicada (CIQA), Blvd. Enrique Reyna Hermosillo No. 140, C.P.25250 Saltillo, Coahuila, Mexico
E-mail: rziolo@cs.com

Abstract

The synthesis of 18F-labelled positron emitting NPs by direct irradiation of 18O-enriched aluminum oxide NPs with 16 MeV protons is reported. Biodistribution studies of the labelled particles after intravenous administration were performed in male rats using positron emission tomography. The simple and general activation strategy can be applied to any in situ prepared core metal oxide particle for direct use or subsequent bio-compatible coating or encapsulation followed by functionalization.

Graphical abstract: Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

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Article information

DOI
https://doi.org/10.1039/C2AN35863H
Article type
Communication
Submitted
25 Jun 2012
Accepted
24 Aug 2012
First published
28 Aug 2012

Analyst, 2012,137, 4902-4906

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Tracing nanoparticles in vivo: a new general synthesis of positron emitting metal oxide nanoparticles by proton beam activation

C. Pérez-Campaña, V. Gómez-Vallejo, A. Martin, E. San Sebastián, S. E. Moya, T. Reese, R. F. Ziolo and J. Llop, Analyst, 2012, 137, 4902 DOI: 10.1039/C2AN35863H

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