Chemiluminescence determination of ibuprofen and ketoprofen using the Fenton system in the presence of europium(iii) ions

Abstract

A simple new chemiluminescent method for the determination of ibuprofen (IB) and ketoprofen (KP) is described. The method for the determination of ibuprofen is based on the europium(III) emission as a result of the energy transfer process from the excited product of the ibuprofen oxidation in the Fenton system to the uncomplexed Eu(III). The detection limit of ibuprofen is 6 × 10⁻⁸ mol L⁻¹. The method was successfully applied to the determination of IB in a mixture of non-steroidal anti-inflammatory drugs, pharmaceutical formulations and urine.