Issue 10, 2012

Selective solid-phase extraction using molecularly imprinted polymers for the analysis of norfloxacin in fish

Abstract

A highly selective imprinted sorbent was prepared by a surface molecular imprinting technique, and used for solid phase extraction-high performance liquid chromatography (SPE-HPLC) to determine trace norfloxacin (NOF) in complicated samples. The molecularly imprinted polymer (MIP) was obtained by using NOF as the template, β-cyclodextrin-methyl methacrylate (β-CD-MMA) and acrylamide (AM) as functional monomers, ethylene glycol dimethacrylate (EDMA) as the cross-linking agent and toluene as the porogen. Various parameters affecting the extraction efficiency of the polymer have been evaluated to optimize the selective preconcentration of the NOF from fish samples. The NOF from fish samples, selectively extracted by MIP, was detected by RP-HPLC. The MISPE-HPLC method showed high selectivity and good recoveries (>85.7%). It was demonstrated that this MISPE-HPLC method could be applied for direct preconcentration and determination of quinolones in real samples.

Graphical abstract: Selective solid-phase extraction using molecularly imprinted polymers for the analysis of norfloxacin in fish

Article information

Article type
Paper
Submitted
29 May 2012
Accepted
30 Jul 2012
First published
02 Aug 2012

Anal. Methods, 2012,4, 3187-3192

Selective solid-phase extraction using molecularly imprinted polymers for the analysis of norfloxacin in fish

B. Zhang, J. Zhao, B. Sha and M. Xian, Anal. Methods, 2012, 4, 3187 DOI: 10.1039/C2AY25707F

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