Issue 16, 2012

Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

Abstract

We present herein for the first time the asymmetric synthesis of drug-like spiranes through reflexive-Michael reaction by using 2-aminobuta-1,3-enyne catalysis under mild conditions.

Graphical abstract: Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

Supplementary files

Article information

Article type
Communication
Submitted
20 Nov 2011
Accepted
22 Dec 2011
First published
03 Jan 2012

Chem. Commun., 2012,48, 2252-2254

Discovery of 2-aminobuta-1,3-enynes in asymmetric organocascade catalysis: construction of drug-like spirocyclic cyclohexanes having five to six contiguous stereocenters

D. B. Ramachary, C. Venkaiah and P. Murali Krishna, Chem. Commun., 2012, 48, 2252 DOI: 10.1039/C2CC17219D

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