Issue 45, 2012

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Abstract

New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.

Graphical abstract: In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2012
Accepted
17 Apr 2012
First published
01 May 2012

Chem. Commun., 2012,48, 5674-5676

In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues

D. Matthes, L. Richter, J. Müller, A. Denisiuk, S. C. Feifel, Y. Xu, P. Espinosa-Artiles, R. D. Süssmuth and I. Molnár, Chem. Commun., 2012, 48, 5674 DOI: 10.1039/C2CC31669B

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