Issue 65, 2012

Cocrystal dissociation and molecular demixing in the solid state

Abstract

A new cocrystal containing caffeine and theophylline was found to dissociate on heating, with caffeine and theophylline molecules spontaneously demixing and recrystallizing as separate phases, in a solid–solid transition likely driven by an increase in entropy. The morphology and composition of the resulting crystals was determined by transmission electron microscopy.

Graphical abstract: Cocrystal dissociation and molecular demixing in the solid state

Supplementary files

Article information

Article type
Communication
Submitted
11 May 2012
Accepted
26 Jun 2012
First published
28 Jun 2012

Chem. Commun., 2012,48, 8075-8077

Cocrystal dissociation and molecular demixing in the solid state

M. D. Eddleston, G. O. Lloyd and W. Jones, Chem. Commun., 2012, 48, 8075 DOI: 10.1039/C2CC33412G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements