Issue 86, 2012

Zirconium catalyzed alkyne dimerization for selective Z-enyne synthesis

Abstract

The regioselective head-to-head dimerization of alkynes is catalyzed by a dibenzyl tethered bis(ureate) zirconium precatalyst with aniline as an additive. This system also gives outstanding stereoselectivity to furnish Z-enynes in high yields. A dinuclear reactive intermediate has been characterized, which provides a potential mechanistic rationale for the unexpected regio- and stereoselectivity in this catalytic system.

Graphical abstract: Zirconium catalyzed alkyne dimerization for selective Z-enyne synthesis

Supplementary files

Article information

Article type
Communication
Submitted
15 Aug 2012
Accepted
06 Sep 2012
First published
07 Sep 2012

Chem. Commun., 2012,48, 10609-10611

Zirconium catalyzed alkyne dimerization for selective Z-enyne synthesis

R. H. Platel and L. L. Schafer, Chem. Commun., 2012, 48, 10609 DOI: 10.1039/C2CC35913H

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