Issue 8, 2012

An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant

Abstract

An efficient Cu-catalyzed formation of tetra-substituted pyrazoles is reported. In this atom economic process, readily available enamines and nitriles are reacted by C–C and N–N bond formation. Oxygen has been successfully used as the oxidant, which has important economic and environmental advantages. A broad scope of enamines and nitriles can be utilized in this process.

Graphical abstract: An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant

Supplementary files

Article information

Article type
Paper
Submitted
29 Mar 2012
Accepted
29 May 2012
First published
30 May 2012

Green Chem., 2012,14, 2193-2196

An efficient copper-catalyzed formation of highly substituted pyrazoles using molecular oxygen as the oxidant

M. Suri, T. Jousseaume, J. J. Neumann and F. Glorius, Green Chem., 2012, 14, 2193 DOI: 10.1039/C2GC35476D

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