Issue 4, 2013

Non-traditional roles of G protein-coupled receptors in basic cell biology

Abstract

G protein-coupled receptors (GPCRs) are key signaling proteins that regulate how cells interact with their environment. Traditional signaling cascades involving GPCRs have been well described and are well established and very important clinical targets. With the development of more recent technologies, hints about the involvement of GPCRs in fundamental cell biological processes are beginning to emerge. In this review, we give a basic introduction to GPCR signaling and highlight some less well described roles of GPCRs, including in cell division and membrane trafficking, which may occur through canonical and non-canonical signaling pathways.

Graphical abstract: Non-traditional roles of G protein-coupled receptors in basic cell biology

Article information

Article type
Review Article
Submitted
10 Oct 2012
Accepted
30 Nov 2012
First published
17 Dec 2012

Mol. BioSyst., 2013,9, 586-595

Non-traditional roles of G protein-coupled receptors in basic cell biology

X. Zhang and U. S. Eggert, Mol. BioSyst., 2013, 9, 586 DOI: 10.1039/C2MB25429H

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