Issue 9, 2012
From the journal:

MedChemComm

Self-complexation and complexation-controlled target cancer therapy†

Li Li,a   Ming Zhao,*a   Wenhao Li,a   Yuji Wang,a   Zhuge Zhang,a   Ran Ana  and  Shiqi Peng*a  

* Corresponding authors

a College of Pharmaceutical Sciences, Capital Medical University, Beijing, P.R. China
E-mail: mzhao@mail.bjum.edu.cn, sqpeng@mail.bjum.edu.cn
Fax: +86-10-8391-1528; +86 10 83911535
Tel: +86-10-8391-1528

Abstract

Target cancer therapy could be achieved by self-complexation and complexation between β-carboline–β-cyclodextrin and doxorubicin. Self-complex/complex was formed at neutral normal tissues. It converted to complex at acidic tumor tissue. Thus, doxorubicin could be targeted and carried to tumor cells. The survival of mice had been improved.

Graphical abstract: Self-complexation and complexation-controlled target cancer therapy

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Article information

DOI
https://doi.org/10.1039/C2MD20003A
Article type
Concise Article
Submitted
11 Jan 2012
Accepted
01 Apr 2012
First published
16 May 2012

Med. Chem. Commun., 2012,3, 1059-1061

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Self-complexation and complexation-controlled target cancer therapy

L. Li, M. Zhao, W. Li, Y. Wang, Z. Zhang, R. An and S. Peng, Med. Chem. Commun., 2012, 3, 1059 DOI: 10.1039/C2MD20003A

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