Issue 11, 2012
From the journal:

MedChemComm

‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)†

Mathew Stanley,a   Nicholas Cattle,b   John McCauley,b   Stephen R. Martin,c   Abdul Rashid,d   Robert A. Field,d   Benoit Carbaina  and  Hansjörg Streicher*a  

* Corresponding authors

a Chemistry Division, School of Life Sciences, University of Sussex, Brighton, UK
E-mail: h.streicher@sussex.ac.uk
Fax: +44 (0)1273-876687

b WHO Collaborating Centre for Reference and Research on Influenza, Division of Virology, National Institute of Medical Research, Mill Hill, London, UK

c Division of Physical Biochemistry, National Institute of Medical Research, Mill Hill, London, UK

d John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK

Abstract

The strong and selective binding of 2 types of gold nanoparticles that are decorated with the oseltamivir (aka TamifluTM) pharmacophore to wild-type and resistant influenza virus strains, including isolates from the 2009 pandemic, is reported. The particles interact with the virus neuraminidase rather than the hemagglutinin and could serve as a vantage point for novel influenza virus sensors, due to the intrinsic advantages of oseltamivir over the natural sialic acid ligand or even zanamivir.

Graphical abstract: ‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

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Article information

DOI
https://doi.org/10.1039/C2MD20034A
Article type
Concise Article
Submitted
07 Feb 2012
Accepted
06 May 2012
First published
09 May 2012

Med. Chem. Commun., 2012,3, 1373-1376

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‘TamiGold’: phospha-oseltamivir-stabilised gold nanoparticles as the basis for influenza therapeutics and diagnostics targeting the neuraminidase (instead of the hemagglutinin)

M. Stanley, N. Cattle, J. McCauley, S. R. Martin, A. Rashid, R. A. Field, B. Carbain and H. Streicher, Med. Chem. Commun., 2012, 3, 1373 DOI: 10.1039/C2MD20034A

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