Issue 8, 2012

Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

Abstract

Cyclic peptides are at the forefront of efforts to pursue previously ‘undruggable’ therapeutic targets. Increasingly, researchers are adapting natural products and their biosynthetic systems to the preparation of cyclic peptide libraries. Alternatively, extant biotechnologies are being modified to increase the range and diversity of the compounds that they can access and incorporate into natural product motifs. A number of such systems have been validated with lead discovery and optimization against therapeutically relevant targets.

Graphical abstract: Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

Article information

Article type
Review Article
Submitted
06 Mar 2012
Accepted
04 May 2012
First published
09 May 2012

Med. Chem. Commun., 2012,3, 905-915

Biochemical and biosynthetic preparation of natural product-like cyclic peptide libraries

A. A. Bowers, Med. Chem. Commun., 2012, 3, 905 DOI: 10.1039/C2MD20068F

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