Issue 10, 2012

Recent applications of multicomponent reactions in medicinal chemistry

Abstract

Multicomponent reactions are flexible reactions for the rapid generation of complex molecules with often biologically relevant scaffold structures. Combined with the ease of parallelization and the exploratory power with regard to chemical space, multicomponent reactions have attracted significant attention from the medicinal chemistry community. In this Review, we present an overview of recent literature concerning this topic to provide insight into the applications of multicomponent reactions in this field.

Graphical abstract: Recent applications of multicomponent reactions in medicinal chemistry

Article information

Article type
Review Article
Submitted
09 Apr 2012
Accepted
14 Jun 2012
First published
25 Jul 2012

Med. Chem. Commun., 2012,3, 1189-1218

Recent applications of multicomponent reactions in medicinal chemistry

P. Slobbe, E. Ruijter and R. V. A. Orru, Med. Chem. Commun., 2012, 3, 1189 DOI: 10.1039/C2MD20089A

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