Issue 8, 2012

Informatic strategies for the discovery of polyketides and nonribosomal peptides

Abstract

Modern medicine underwent a major transformation when microbes were first industrially exploited for their ability to produce antibiotic agents. These natural products often belonged to two classes, known as polyketides and nonribosomal peptides. Exhaustive bioactivity screening has lead to the discovery of hundreds of these bioactive compounds, whose rediscovery confounds new exploratory efforts. Still, microbial genomes have shown us that there are many more polyketides and nonribosomal peptides remaining to be discovered. A modern challenge and opportunity exists in our ability to link genomic and metabolomic data, using novel informatic methods to find new bioactive natural products. This “genome-mining” approach, along with other recent informatic platforms for discovering polyketides and nonribosomal peptides will be the focus of this review.

Graphical abstract: Informatic strategies for the discovery of polyketides and nonribosomal peptides

Article information

Article type
Review Article
Submitted
10 May 2012
Accepted
25 Jun 2012
First published
17 Jul 2012

Med. Chem. Commun., 2012,3, 932-937

Informatic strategies for the discovery of polyketides and nonribosomal peptides

C. Johnston, A. Ibrahim and N. Magarvey, Med. Chem. Commun., 2012, 3, 932 DOI: 10.1039/C2MD20120H

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