Issue 10, 2012
From the journal:

MedChemComm

Phosphofructokinase: structural and functional aspects and design of selective inhibitors

Stefânia N. Lavorato,a   Saulo F. Andrade,a   Thaïs H. A. Silva,a   Ricardo J. Alvesa  and  Renata B. Oliveira*a  

* Corresponding authors

a Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil
E-mail: renatabo@farmacia.ufmg.br
Fax: +55-31-3409-6935
Tel: +55-31-3409-6395

Abstract

Phosphofructokinase is an enzyme of central importance to carbohydrate metabolism and is subject to regulation by a considerable number of allosteric ligands. This review is a survey of the recent literature concerning structural and functional properties of the enzyme phosphofructokinase as well as its importance as target for the development of selective therapeutics for trypanosomiasis.

Graphical abstract: Phosphofructokinase: structural and functional aspects and design of selective inhibitors

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Article information

DOI
https://doi.org/10.1039/C2MD20122D
Article type
Review Article
Submitted
10 May 2012
Accepted
17 Jun 2012
First published
19 Jun 2012

Med. Chem. Commun., 2012,3, 1219-1227

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Phosphofructokinase: structural and functional aspects and design of selective inhibitors

S. N. Lavorato, S. F. Andrade, T. H. A. Silva, R. J. Alves and R. B. Oliveira, Med. Chem. Commun., 2012, 3, 1219 DOI: 10.1039/C2MD20122D

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