Issue 9, 2012
From the journal:

Natural Product Reports

The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

Pascal Belin,†a   Mireille Moutiez,†a   Sylvie Lautru,b   Jérôme Seguin,a   Jean-Luc Pernodetb  and  Muriel Gondry*a  

* Corresponding authors

a CEA, Institut de Biologie et Technologies de Saclay, F-91191 Gif-sur-Yvette, France
E-mail: muriel.gondry@cea.fr
Fax: + 33 169 08 90 71
Tel: +33 169 08 76 47

b Univ. Paris-Sud, CNRS, UMR8621, Institut de Génétique et Microbiologie, F-91405 Orsay, France

Abstract

Covering: up to 2012

We review here work on the biosynthesis of diketopiperazines (DKPs), a large class of natural products with noteworthy biological activities, focusing on the biosynthetic pathways involving cyclodipeptide synthases (CDPSs), a newly defined family of enzymes. Distinct from nonribosomal peptide synthetases (NRPSs), the other family of enzymes synthesizing DKPs, CDPSs bridge the primary and secondary metabolic pathways by hijacking aminoacyl-tRNAs to produce DKPs. This review includes a comprehensive description of the state of the art for CDPS-dependent pathways, and highlights the ways in which this knowledge could be used to increase the diversity of natural DKPs by pathway engineering.

Graphical abstract: The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

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Article information

DOI
https://doi.org/10.1039/C2NP20010D
Article type
Review Article
Submitted
27 Jan 2012
First published
03 Jul 2012

Nat. Prod. Rep., 2012,29, 961-979

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The nonribosomal synthesis of diketopiperazines in tRNA-dependent cyclodipeptide synthase pathways

P. Belin, M. Moutiez, S. Lautru, J. Seguin, J. Pernodet and M. Gondry, Nat. Prod. Rep., 2012, 29, 961 DOI: 10.1039/C2NP20010D

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