Issue 2, 2013

Biosynthesis of thiopeptide antibiotics and their pathway engineering

Abstract

Covering: 2009 to 2012

Thiopeptide antibiotics, a growing class of highly modified polythiazolyl peptides, have long been known for their remarkable bioactivities and unusual modes of actions. Uncovering of the ribosomal origin of thiopeptides now sets the stage for appreciating the initially undervalued modifications of the precursor peptides to afford the astonishing structure complexity. In this Highlight, we discuss the advances during the past four years in understanding the generality and specificity of thiopeptide biosynthesis, and on this basis, in expanding the structural diversity by pathway engineering.

Graphical abstract: Biosynthesis of thiopeptide antibiotics and their pathway engineering

Article information

Article type
Highlight
Submitted
30 Oct 2012
First published
19 Dec 2012

Nat. Prod. Rep., 2013,30, 218-226

Biosynthesis of thiopeptide antibiotics and their pathway engineering

Q. Zhang and W. Liu, Nat. Prod. Rep., 2013, 30, 218 DOI: 10.1039/C2NP20107K

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