Issue 2, 2012

Phenylboronic acid functionalized gold nanoparticles for highly sensitive detection ofStaphylococcus aureus

Abstract

Herein, we report a phenylboronic acid functionalized gold nanoparticle (GNP)-based colorimetric assay for rapid detection ofStaphylococcus aureus (S. aureus) with high sensitivity. In this approach, GNPs can bind to S. aureus by the reaction of phenylboronic acid with the cis-diol configuration in glycans on the bacterial surface, providing a colorimetric readout of the binding event. Using this strategy, we have been able to quantify S. aureus at a concentration of 50 cells per mL (three times the standard deviation divided by the slope of the working curve) in aqueous solution.

Graphical abstract: Phenylboronic acid functionalized gold nanoparticles for highly sensitive detection ofStaphylococcus aureus

Supplementary files

Article information

Article type
Communication
Submitted
04 Nov 2011
Accepted
25 Nov 2011
First published
29 Nov 2011

Nanoscale, 2012,4, 451-454

Phenylboronic acid functionalized gold nanoparticles for highly sensitive detection ofStaphylococcus aureus

J. Wang, J. Gao, D. Liu, D. Han and Z. Wang, Nanoscale, 2012, 4, 451 DOI: 10.1039/C2NR11657J

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