Issue 19, 2012

Copper(ii)-mediated oxidative cyclization of enamides to oxazoles

Abstract

The copper(II)-mediated oxidative cyclization of enamides to oxazoles is reported. A range of 2,5-disubstituted oxazoles were prepared in moderate to good yields in two steps from simple amide and alkyne precursors.

Graphical abstract: Copper(ii)-mediated oxidative cyclization of enamides to oxazoles

Supplementary files

Article information

Article type
Paper
Submitted
11 Feb 2012
Accepted
22 Mar 2012
First published
23 Mar 2012

Org. Biomol. Chem., 2012,10, 3866-3870

Copper(II)-mediated oxidative cyclization of enamides to oxazoles

A. E. Wendlandt and S. S. Stahl, Org. Biomol. Chem., 2012, 10, 3866 DOI: 10.1039/C2OB25310K

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