Issue 38, 2012
From the journal:

Organic & Biomolecular Chemistry

An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines†

Giorgio Abbiati,a   Antonio Arcadi,*bc   Marco Chiarini,d   Fabio Marinelli,b   Emanuela Pietropaolob  and  Elisabetta Rossia  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche-Sezione di Chimica generale e Organica “A. Marchesini”, Università degli Studi di Milano, Via G. Venezian 21, 20133 Milano, Italy

b Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi di L'Aquila, Via Vetoio, 67010 Coppito, L'Aquila, Italy
E-mail: antonio.arcadi@univaq.it
Fax: +390862433033

c Unità di Ricerca AQ2, Consorzio Interuniversitario La Chimica per l'Ambiente, Via della Libertà 5/12, 30175 Marghera, VE, Italy

d Department of Food Science, University of Teramo, Via Carlo Lerici 1, I-64023 Mosciano Sant'Angelo, TE, Italy

Abstract

A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures.

Graphical abstract: An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines

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Article information

DOI
https://doi.org/10.1039/C2OB26380G
Article type
Paper
Submitted
17 Jul 2012
Accepted
09 Aug 2012
First published
10 Aug 2012

Org. Biomol. Chem., 2012,10, 7801-7808

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An alternative one-pot gold-catalyzed approach to the assembly of 11H-indolo[3,2-c]quinolines

G. Abbiati, A. Arcadi, M. Chiarini, F. Marinelli, E. Pietropaolo and E. Rossi, Org. Biomol. Chem., 2012, 10, 7801 DOI: 10.1039/C2OB26380G

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