Issue 9, 2012
From the journal:

Photochemical & Photobiological Sciences

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen†‡

Rubén Ruiz-González,a   John H. White,b   Montserrat Agut,a   Santi Nonell*a  and  Cristina Flors*bc  

* Corresponding authors

a IQS School of Engineering, Universitat Ramon Llull, Vía Augusta 390, Barcelona, Spain
E-mail: santi.nonell@iqs.url.edu
Fax: +34 932056266
Tel: +34 932672000

b EastChem School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Rd, Edinburgh, UK

c IMDEA Nanociencia, C/Faraday 9, Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain
E-mail: cristina.flors@imdea.org
Fax: +34 91 397 6855
Tel: +34 91 397 6851

Abstract

TagRFP, a fluorescent protein capable of photosensitizing the production of singlet oxygen, was expressed in E. coli. Subsequent exposure to green light induced bacterial cell death in a light-dose dependent manner. It is demonstrated for the first time that intracellular singlet oxygen is sufficient to kill bacteria.

Graphical abstract: A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2PP25126D
Article type
Communication
Submitted
29 Apr 2012
Accepted
30 May 2012
First published
13 Jun 2012

Photochem. Photobiol. Sci., 2012,11, 1411-1413

Permissions

Request permissions

A genetically-encoded photosensitiser demonstrates killing of bacteria by purely endogenous singlet oxygen

R. Ruiz-González, J. H. White, M. Agut, S. Nonell and C. Flors, Photochem. Photobiol. Sci., 2012, 11, 1411 DOI: 10.1039/C2PP25126D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements