Issue 34, 2012

Biocompatible and biodegradable polymersomes as delivery vehicles in biomedical applications

Abstract

Biocompatible and biodegradable polymersomes are commonly self-assembled from amphiphilic diblock copolymers composed of hydrophilic poly(ethylene glycol) (PEG) or poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) segments and hydrophobic polyester blocks, such as poly(lactic acid) (PLA) or poly(ε-caprolactone) (PCL). Such polymersomes have emerged as promising delivery vehicles for pharmaceutical applications. Presented in this review are summaries of recent developments of biocompatible and biodegradable polymersomes, including self-assembly, encapsulation of various therapeutics, pH-induced hydrolysis for controlled release as well as their functionalization and intelligent design.

Graphical abstract: Biocompatible and biodegradable polymersomes as delivery vehicles in biomedical applications

Article information

Article type
Highlight
Submitted
28 Mar 2012
Accepted
03 May 2012
First published
14 Jun 2012

Soft Matter, 2012,8, 8811-8821

Biocompatible and biodegradable polymersomes as delivery vehicles in biomedical applications

G. Liu, C. Chen and J. Ji, Soft Matter, 2012, 8, 8811 DOI: 10.1039/C2SM25721A

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