Spatial confinement instigates environmental determination of neuronal polarity

Dawn M. Johnson; Jad P. Abi-Mansour; Joshua A. Maurer

doi:10.1039/C2IB20126G

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Spatial confinement instigates environmental determination of neuronal polarity†

Dawn M. Johnson,^a Jad P. Abi-Mansour^a and Joshua A. Maurer*^a

Author affiliations

* Corresponding authors

^a Washington University in St. Louis, Department of Chemistry and Center for Materials Innovation, Campus Box 1134, One Brookings Drive, St. Louis, USA
E-mail: maurer@wustl.edu
Fax: +1-314-935-4481
Tel: +1-314-935-4695

Abstract

Here we used patterned self-assembled monolayer (SAM) chemistry to explore the role of spatial confinement on the growth and proliferation of a developing neuron. Despite extensive previous work on the molecular mechanisms controlling these processes, classical biological approaches have not been able to clearly distinguish whether differentiation is predetermined or environmentally determined.