Issue 5, 2013

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein

Abstract

The template effect of 14-3-3 protein on the chemical ligation of fusicoccin derivatives containing an epoxide group and the pentapeptide QSYDC was investigated. HPLC analysis of the epoxide-opening reaction demonstrated that 14-3-3ζ protein improves the yield of the conjugate product compared to the protein-free control.

Graphical abstract: Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein

Supplementary files

Article information

Article type
Communication
Submitted
22 Sep 2012
Accepted
15 Nov 2012
First published
28 Nov 2012

Mol. BioSyst., 2013,9, 940-943

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein

T. Maki, A. Kawamura, N. Kato and J. Ohkanda, Mol. BioSyst., 2013, 9, 940 DOI: 10.1039/C2MB25388G

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