Issue 17, 2013

Biomolecular dual-ion-trap mass analyzer

Abstract

We developed the first dual-ion-trap mass analyzer which can detect ions with a high mass-to-charge ratio (m/z > 6000). The first ion trap is a quadrupole ion trap (QIT), which was operated by step scanning of the trapping frequency for a sample containing mixtures of biomolecules. The second ion trap, linear ion trap (LIT), was utilized to capture selected ions ejected out of the QIT so that all ions from the QIT can be examined one by one. It was found that the ions can be transferred from the QIT to the LIT with ∼60% efficiency for large biomolecular ions with high m/z. This is by far the highest transfer efficiency in the dual ion trap device for high-mass ions.

Graphical abstract: Biomolecular dual-ion-trap mass analyzer

Article information

Article type
Paper
Submitted
02 Apr 2013
Accepted
08 Jun 2013
First published
11 Jun 2013

Analyst, 2013,138, 4823-4829

Biomolecular dual-ion-trap mass analyzer

Y. Hsu, J. Lin, M. Chu and C. Chen, Analyst, 2013, 138, 4823 DOI: 10.1039/C3AN00653K

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