Issue 24, 2013

Direct molecular detection of SRY gene from unamplified genomic DNA by metal-enhanced fluorescence and FRET

Abstract

A biosensor based on a cationic polymer and metal@silica core–shell nanoparticles is demonstrated for the rapid identification of the SRY gene from unamplified human genomic DNA. By amplifying the fluorescence signal triggered by the capture of target molecules, this biosensor avoids the added complexity of enzyme-based chemical amplification, makes genotyping assays faster and less costly and could have important applications in various areas of health sciences.

Graphical abstract: Direct molecular detection of SRY gene from unamplified genomic DNA by metal-enhanced fluorescence and FRET

Supplementary files

Article information

Article type
Communication
Submitted
19 Aug 2013
Accepted
19 Sep 2013
First published
19 Sep 2013

Anal. Methods, 2013,5, 6896-6899

Direct molecular detection of SRY gene from unamplified genomic DNA by metal-enhanced fluorescence and FRET

D. Brouard, O. Ratelle, A. G. Bracamonte, M. St-Louis and D. Boudreau, Anal. Methods, 2013, 5, 6896 DOI: 10.1039/C3AY41428K

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