Issue 11, 2013

Collagen-based substrates with tunable strength for soft tissue engineering

Abstract

Through the use of mechanical reinforcement of collagen matrices, mechanically strong and compliant 3D tissue mimetic scaffolds can be generated that act as scaffolds for soft tissue engineering. Collagen has been widely used for the development of materials for repair, augmentation or replacement of damaged or diseased tissue. Herein we describe a facile method for the layer-by-layer fabrication of robust planar collagen fiber constructs. Collagen gels cast in a phosphate buffer were dried to form dense collagen mats. Subsequent gels were layered and dried atop mats to create multilayer constructs possessing a range of tunable strengths (0.5–11 MPa) and stiffness (1–115 MPa). Depending on processing conditions and crosslinking of constructs, strain to failure ranged between 9 to 48%. Collagen mats were constructed into hernia patches that prevented hernia recurrence in Wistar rats.

Graphical abstract: Collagen-based substrates with tunable strength for soft tissue engineering

Article information

Article type
Paper
Submitted
16 May 2013
Accepted
23 Jul 2013
First published
09 Aug 2013

Biomater. Sci., 2013,1, 1193-1202

Collagen-based substrates with tunable strength for soft tissue engineering

V. A. Kumar, J. M. Caves, C. A. Haller, E. Dai, L. Liu, S. Grainger and E. L. Chaikof, Biomater. Sci., 2013, 1, 1193 DOI: 10.1039/C3BM60129C

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