Issue 74, 2013

Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

Abstract

A parallel, versatile and efficient route to synthesis of pyrrolidinoindoline and tetrahydrofuranoindoline alkaloids from cinnamyl derivatives has been developed, featuring a domino Rh-catalyzed hydroformylation–double cyclization sequence. This method can be applied to the syntheses of anti-Alzheimer drugs such as physostigmine and physovenine.

Graphical abstract: Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

Supplementary files

Article information

Article type
Communication
Submitted
02 May 2013
Accepted
15 Jul 2013
First published
17 Jul 2013

Chem. Commun., 2013,49, 8232-8234

Domino Rh-catalyzed hydroformylation–double cyclization of o-amino cinnamyl derivatives: applications to the formal total syntheses of physostigmine and physovenine

W. Chiou, C. Kao, J. Tsai and Y. Chang, Chem. Commun., 2013, 49, 8232 DOI: 10.1039/C3CC43257B

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