Issue 93, 2013

Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

Abstract

The corrole-based catalytic antioxidant 1-Fe reduced the cholesterol biosynthesis ability of macrophages, harvested from mice treated with it. 1-Fe and a non-redox active analogue of it affect the committed step of the biosynthetic pathway – the HMG-CoA reductase catalysed reaction – by acting as allosteric inhibitors of this key enzyme.

Graphical abstract: Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

Supplementary files

Article information

Article type
Communication
Submitted
24 Jun 2013
Accepted
25 Jul 2013
First published
26 Jul 2013

Chem. Commun., 2013,49, 10917-10919

Allosteric inhibitors of HMG-CoA reductase, the key enzyme involved in cholesterol biosynthesis

A. Haber, A. Abu-Younis Ali, M. Aviram and Z. Gross, Chem. Commun., 2013, 49, 10917 DOI: 10.1039/C3CC44740E

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