Issue 96, 2013
From the journal:

Chemical Communications

Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks†

Andrew D. Burrows,*a   Monika Jurcic,a   Luke L. Keenan,a   Rebecca A. Lane,a   Mary F. Mahon,*a   Mark R. Warren,b   Harriott Nowell,b   Michael Paradowskic  and  John Spencer*c  

* Corresponding authors

a Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
E-mail: a.d.burrows@bath.ac.uk, m.f.mahon@bath.ac.uk
Tel: +44 (0)1225 386529

b Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxon, UK

c Department of Chemistry, School of Life Sciences, University of Sussex, Falmer, Brighton, East Sussex, UK
E-mail: j.spencer@sussex.ac.uk
Tel: +44 (0)1273 877374

Abstract

A series of new zinc-based metal–organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.

Graphical abstract: Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC45689G
Article type
Communication
Submitted
25 Jul 2013
Accepted
09 Oct 2013
First published
17 Oct 2013

Chem. Commun., 2013,49, 11260-11262

Permissions

Request permissions

Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal–organic frameworks

A. D. Burrows, M. Jurcic, L. L. Keenan, R. A. Lane, M. F. Mahon, M. R. Warren, H. Nowell, M. Paradowski and J. Spencer, Chem. Commun., 2013, 49, 11260 DOI: 10.1039/C3CC45689G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements