Issue 2, 2014

Multifunctional MnO2 nanosheet-modified Fe3O4@SiO2/NaYF4:Yb, Er nanocomposites as novel drug carriers

Abstract

We report on a novel drug carrier which is based on the combination of magnetic and upconversion (UC) emission of Fe3O4@SiO2/NaYF4:Yb, Er (MSU) hybrids modified with MnO2 nanosheets (MSU/MnO2). The MSU hybrids were fabricated by covalently linking amino-modified Fe3O4@SiO2 particles with carboxyl-functionalized NaYF4:Yb, Er particles. The Fe3O4 core and the NaYF4:Yb, Er shell functioned successfully for magnetic targeting and fluorescence imaging, respectively. MnO2 nanosheets served as drug carriers and UC luminescence quenchers. The drug can be released by introducing glutathione (GSH) which reduces MnO2 to Mn2+, and at the same time, UC luminescence can be turned on. These results clearly show that these MSU/MnO2 nanocomposites are promising platforms which can be applied to construct a smart drug delivery system with magnetic targeting and GSH-stimulation, as well as tracking by UC luminescence.

Graphical abstract: Multifunctional MnO2 nanosheet-modified Fe3O4@SiO2/NaYF4:Yb, Er nanocomposites as novel drug carriers

Supplementary files

Article information

Article type
Paper
Submitted
31 Jul 2013
Accepted
06 Sep 2013
First published
06 Sep 2013

Dalton Trans., 2014,43, 451-457

Multifunctional MnO2 nanosheet-modified Fe3O4@SiO2/NaYF4:Yb, Er nanocomposites as novel drug carriers

P. Zhao, Y. Zhu, X. Yang, J. Shen, X. Jiang, J. Zong and C. Li, Dalton Trans., 2014, 43, 451 DOI: 10.1039/C3DT52066H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements