Issue 48, 2013

A new design for nucleolipid-based Ru(iii) complexes as anticancer agents

Abstract

In continuation with our studies concerning the synthesis, characterization and biological evaluation of nucleolipidic Ru(III) complexes, a novel design for this family of potential anticancer agents is presented here. As a model compound, a new uridine-based nucleolipid has been prepared, named HoUrRu, following a simple and versatile synthetic procedure, and converted into a Ru(III) salt. Stable formulations of this highly functionalized Ru(III) complex have been obtained by co-aggregation with either the zwitterionic lipid POPC or the cationic DOTAP, which have been subjected to an in-depth microstructural characterization, including DLS, SANS and EPR measurements. The in vitro bioactivity profile of HoUrRu, as a pure compound or in formulation with POPC or DOTAP, reveals high antiproliferative activity against MCF-7 and WiDr human cancer cell lines.

Graphical abstract: A new design for nucleolipid-based Ru(iii) complexes as anticancer agents

Supplementary files

Article information

Article type
Paper
Submitted
24 Aug 2013
Accepted
24 Sep 2013
First published
24 Sep 2013

Dalton Trans., 2013,42, 16697-16708

A new design for nucleolipid-based Ru(III) complexes as anticancer agents

D. Montesarchio, G. Mangiapia, G. Vitiello, D. Musumeci, C. Irace, R. Santamaria, G. D'Errico and L. Paduano, Dalton Trans., 2013, 42, 16697 DOI: 10.1039/C3DT52320A

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