Issue 10, 2014

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Abstract

A series of ruthenium(II) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL−1) and minimum bactericidal concentration (MBC, 25 μg mL−1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL−1 and MBC = 100 μg mL−1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL−1, MBC, >100 μg mL−1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Graphical abstract: Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Supplementary files

Article information

Article type
Paper
Submitted
13 Oct 2013
Accepted
14 Dec 2013
First published
16 Dec 2013

Dalton Trans., 2014,43, 3949-3957

Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

P.-L. Lam, G.-L. Lu, K.-M. Hon, K.-W. Lee, C.-L. Ho, X. Wang, J. C.-O. Tang, K.-H. Lam, R. S.-M. Wong, S. H.-L. Kok, Z.-X. Bian, H. Li, K. K.-H. Lee, R. Gambari, C.-H. Chui and W.-Y. Wong, Dalton Trans., 2014, 43, 3949 DOI: 10.1039/C3DT52879K

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