Issue 23, 2013

Combinatorial generation of droplets by controlled assembly and coalescence

Abstract

We describe a microfluidic system for generating a sequence of liquid droplets of multiple concentrations in a single experimental condition. The series of final droplets has the combination of the compositions varying periodically, with polydispersity of the size less than 8%. By utilizing the design of the microchannel geometry and the passive control of three immiscible fluids (oil, water, and air) including generation, breakup, separation and coalescence of droplets, we can change the system to generate diverse sets of combination of materials. The device can be used for testing different concentration of materials in picoliter volumes and developing a new way to deliver dynamic signals of chemicals with microfluidics.

Graphical abstract: Combinatorial generation of droplets by controlled assembly and coalescence

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug 2013
Accepted
25 Sep 2013
First published
26 Sep 2013

Lab Chip, 2013,13, 4674-4680

Combinatorial generation of droplets by controlled assembly and coalescence

E. Um, M. E. Rogers and H. A. Stone, Lab Chip, 2013, 13, 4674 DOI: 10.1039/C3LC50957E

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