Issue 4, 2014
From the journal:

Lab on a Chip

Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery†

Wei Wang,‡a   Yan Yan,‡b   Chun Wei Li,b   Huan Ming Xia,a   Siew Shuen Chao,b   De Yun Wang*b  and  Zhi Ping Wang*a  

* Corresponding authors

a Singapore Institute of Manufacturing Technology, 71 Nanyang Drive, Singapore
E-mail: zpwang@SIMTech.a-star.edu.sg

b Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
E-mail: entwdy@nus.edu.sg

Abstract

Cell models based on human nasal epithelial stem/progenitor cells (hNESPCs) are developed to obtain functional ciliated cells on modified Transwell inserts. The live hNECs are integrated into microfluidic platforms to mimic the 3D features of the human upper airway for in vitro testing of gaseous formaldehyde toxicity via airway delivery.

Graphical abstract: Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery

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Article information

DOI
https://doi.org/10.1039/C3LC51208H
Article type
Communication
Submitted
25 Oct 2013
Accepted
28 Nov 2013
First published
28 Nov 2013

Lab Chip, 2014,14, 677-680

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Live human nasal epithelial cells (hNECs) on chip for in vitro testing of gaseous formaldehyde toxicity via airway delivery

W. Wang, Y. Yan, C. W. Li, H. M. Xia, S. S. Chao, D. Y. Wang and Z. P. Wang, Lab Chip, 2014, 14, 677 DOI: 10.1039/C3LC51208H

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