Issue 17, 2013

Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions

Abstract

A concise and practical Cu-catalyzed protocol for the preparation of chloro- and bromoarenes via C–H bond activation has been developed. The advantages of this strategy are the employment of cheap Cu(NO3)2·3H2O, LiX and O2, and its compatibility with both electron-donating and electron-withdrawing substituents on aryl rings.

Graphical abstract: Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions

Supplementary files

Article information

Article type
Communication
Submitted
28 Jan 2013
Accepted
15 Feb 2013
First published
20 Feb 2013

Org. Biomol. Chem., 2013,11, 2756-2760

Copper-catalyzed aromatic C–H bond halogenation with lithium halides under aerobic conditions

S. Mo, Y. Zhu and Z. Shen, Org. Biomol. Chem., 2013, 11, 2756 DOI: 10.1039/C3OB40185E

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