Issue 16, 2013

Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

Abstract

Rapid thiolate exchange of dimethylarsonium, Me2As+, is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.

Graphical abstract: Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

Supplementary files

Article information

Article type
Communication
Submitted
05 Feb 2013
Accepted
04 Mar 2013
First published
05 Mar 2013

Org. Biomol. Chem., 2013,11, 2578-2581

Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts

D. S. Bohle and Y. Gu, Org. Biomol. Chem., 2013, 11, 2578 DOI: 10.1039/C3OB40268A

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