Issue 38, 2013

A one-pot coupling–addition–cyclocondensation sequence (CACS) to 2-substituted 3-acylpyrroles initiated by a copper-free alkynylation

Abstract

A novel three-component synthesis of 2-substituted 3-acylpyrroles can be initiated by a copper-free Pd-catalyzed alkynylation in a one-pot fashion. The reaction sequence proceeds under mild reaction conditions and in moderate to good yields with a broad scope of diversity.

Graphical abstract: A one-pot coupling–addition–cyclocondensation sequence (CACS) to 2-substituted 3-acylpyrroles initiated by a copper-free alkynylation

Supplementary files

Article information

Article type
Paper
Submitted
19 Jun 2013
Accepted
24 Jul 2013
First published
25 Jul 2013

Org. Biomol. Chem., 2013,11, 6556-6561

A one-pot coupling–addition–cyclocondensation sequence (CACS) to 2-substituted 3-acylpyrroles initiated by a copper-free alkynylation

J. Nordmann and T. J. J. Müller, Org. Biomol. Chem., 2013, 11, 6556 DOI: 10.1039/C3OB41269E

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